Endocrine Abstracts

The vasoactive peptide adrenomedullin (ADM) has effects on several vascular beds including the cerebral circulation. The peptide has a positive impact on blood-brain-barrier (BBB) integrity, and transcription of ADM mRNA is enhanced by pro-inflammatory cytokines, IL-1 and TNF-alpha in neuronal cell types. The current study has investigated whether ADM may be a marker for disease progression, in vivo in experimental allergic encephalomyelitis (EAE), a model of the human disease...